The results of most multiple-meal human studies suggest that Ca supplementation will have only a small effect on Fe absorption unless habitual Ca consumption is very low. Outcome analyses showed that Ca supplements had no effect on Fe status in infants fed Fe-fortified formula, lactating women, adolescent girls and adult men and women. However it should be noted that the subjects studied had adequate intakes of bioavailable Fe and, except in one study, had relatively high habitual Ca intakes.
Although cross-sectional analyses in Europe have shown a significant inverse correlation between Ca intake derived primarily from dairy foods and Fe stores, the quantitative effect was relatively small. M Brune Search articles by 'M Brune'. Brune M ,. A Gleerup Search articles by 'A Gleerup'. Gleerup A. Affiliations 1 author 1.
Share this article Share with email Share with twitter Share with linkedin Share with facebook. Abstract We investigated the inhibitory effect of calcium on iron absorption in 57 human subjects. Three studies suggested that the effect is not located in the gastrointestinal tract. The presence of phytate in a meal and formation of calcium-iron-phytate complexes is not a prerequisite for the inhibition. The relative increase in iron absorption by ascorbic acid was the same in meals with and without calcium, suggesting that calcium did not influence the balance between enhancing and inhibiting ligands in the gastrointestinal lumen.
No inhibiting effect on iron absorption was seen when adding 3 mg calcium to 0. Previous studies showing a marked inhibition by calcium had a lower molar ratio, but greater amounts of calcium were given. This suggests that a minimal concentration of calcium is needed to achieve an effect.
The present results indirectly support our original hypothesis that the inhibitory effect of calcium on iron absorption is situated within the intestinal mucosal cells. It is recommended to reduce the intake of dairy products with the main meals providing most of the dietary iron, especially for those having the highest iron requirements i. Role of Dietary Flavonoids in Iron Homeostasis.
Similar Articles To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation. Duration of the inhibitory effect of calcium on non-haem iron absorption in man. Effect of ascorbic acid on iron absorption from different types of meals. Studies with ascorbic-acid-rich foods and synthetic ascorbic acid given in different amounts with different meals. Phytate intake and molar ratios of phytate to zinc, iron and calcium in the diets of people in China.
Is there a physiological role of vitamin C in iron absorption? Phytic acid degradation as a means of improving iron absorption. We explored these possibilities in human intestinal Caco-2 cells cultured in monolayers.
Thus, the effect of Ca on Fe absorption may be of short duration and adaptation may occur with time. This may explain why studies on long-term Ca supplementation of different groups fail to show any adverse effects on Fe status.
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